Tobamoviruses, including tobacco mosaic virus (TMV) and the new tomato brown rugose fruit virus (ToBRFV), can be persistent in greenhouses and other protected cropping environments. Herbaceous ornamentals, vegetables, and tobacco can be affected by tobamoviruses. Once introduced into a site, these viruses can spread rapidly, reducing plant quality and yields. Prevention and careful sanitation are important to maintaining a virus-free production environment for current and future crops.