Target spot and frogeye leaf spot are the major fungal leaf spot diseases of tobacco grown in Kentucky. Burley and dark tobacco are susceptible to these leaf spot diseases; however, dark tobacco tends to be affected to a lesser extent than burley. Yield losses to target spot can exceed 50% in some years; frogeye reduces yields up to 30%, but can affect quality so severely that cured leaf may be declined. Integrated approaches, including good greenhouse production practices, crop rotation, and timely fungicide applications, will optimize management of these diseases.