Grapes grown in Kentucky are subject to environmental stresses that reduce crop yield and quality, and injure and kill grapevines. Damaging critical winter temperatures, late spring frosts, short growing seasons, and extreme summer temperatures all occur with regularity in regions of Kentucky. However, despite the challenging climate, certain species and cultivars of grapes are grown commercially in Kentucky. The aim of this bulletin is to describe the macroclimatic features affecting grape production that should be evaluated in the site selection process and to shorten the trial and error process of finding the best cultivar and climate match.