Honeyvine milkweed is a perennial weed commonly found in Kentucky fields, groves, and orchards. In general, honeyvine milkweed is a difficult weed to control due to its extensive taproot system and rapid growth rate. It is especially difficult to control in permanent crop situations such as plantings of apples, blueberries, and grapes. This is due to the fact that soil tillage is not practiced in orchards, blueberry fields, or vineyards, which would otherwise destroy the root system of honeyvine milkweed and prevent it from getting established.