Production budgets for American, hybrid, European (vinifera), and table grape varieties were updated to estimate grape profitability in Kentucky for 2016. This analysis indicates that wine grapes can be economically feasible in Kentucky when best production practices are followed that maximize yields and when market prices approach $1,200/ton for vinifera wine grapes and $1,000 per ton for French-American and American hybrid wine grape varieties. Sound management that maximizes wine grape yields and minimizes input costs, with marketing that captures top grape prices, is absolutely necessary for economically viable wholesale grape production in Kentucky.